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Dokumenttyp:
journal article 
Autor(en):
Vincent, IE; Zannetti, C; Lucifora, J; Norder, H; Protzer, U; Hainaut, P; Zoulim, F; Tommasino, M; Trépo, C; Hasan, U; Chemin, I 
Titel:
Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. 
Abstract:
Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway. TLR9 is a sensor of viral and bacterial DNA motifs and activates the IRF7 transcription factor which leads to type I IFN secretion by pDCs. However, during chronic hepatitis B virus (HBV) infection, pDCs display an impaired ability to secrete IFN-? following ex vivo stimulation wi...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2011 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
e26315 
Sprache:
eng 
TUM Einrichtung:
r Virologie