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Dokumenttyp:
journal article 
Autor(en):
Russell, HV; Groshen, SG; Ara, T; DeClerck, YA; Hawkins, R; Jackson, HA; Daldrup-Link, HE; Marachelian, A; Skerjanec, A; Park, JR; Katzenstein, H; Matthay, KK; Blaney, SM; Villablanca, JG 
Titel:
A phase I study of zoledronic acid and low-dose cyclophosphamide in recurrent/refractory neuroblastoma: a new approaches to neuroblastoma therapy (NANT) study. 
Abstract:
Zoledronic acid, a bisphosphonate, delays progression of bone metastases in adult malignancies. Bone is a common metastatic site of advanced neuroblastoma. We previously reported efficacy of zoledronic acid in a murine model of neuroblastoma bone invasion prompting this Phase I trial of zoledronic acid with cyclophosphamide in children with neuroblastoma and bone metastases. The primary objective was to determine recommended dosing of zoledronic acid for future trials.Escalating doses of intrave...    »
 
Zeitschriftentitel:
Pediatr Blood Cancer 
Jahr:
2011 
Band / Volume:
57 
Heft / Issue:
Seitenangaben Beitrag:
275-82 
Sprache:
eng 
Print-ISSN:
1545-5009 
TUM Einrichtung:
ntgendiagnostik