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Document type:
journal article 
Author(s):
Kurz, A; Perneczky, R 
Title:
Amyloid clearance as a treatment target against Alzheimer's disease. 
Abstract:
An imbalance between production and clearance of the amyloid-? peptide (A?) is a key momentum of the complex pathological cascade of Alzheimer's disease (AD). It is caused by overproduction of A? or, more frequently, by impaired clearance from brain. Clearance can be reduced by increased aggregation, defective degradation, disturbed balance of transport across the blood-brain barrier, or inefficient peripheral removal of the peptide. In recent years these mechanisms have become targets of pharma...    »
 
Journal title abbreviation:
J Alzheimers Dis 
Year:
2011 
Journal volume:
24 Suppl 2 
Pages contribution:
61-73 
Language:
eng 
Print-ISSN:
1387-2877 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie