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Dokumenttyp:
journal article 
Autor(en):
Klöppel, G 
Titel:
Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. 
Abstract:
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are composed of cells with a neuroendocrine phenotype. The old and the new WHO classifications distinguish between well-differentiated and poorly differentiated neoplasms. All well-differentiated neoplasms, regardless of whether they behave benignly or develop metastases, will be called neuroendocrine tumours (NETs), and graded G1 (Ki67<2%) or G2 (Ki67 2-20%). All poorly differentiated neoplasms will be termed neuroendocrine carcinomas (NECs) and graded G3 (Ki67>20%). To stratify the GEP-NETs and GEP-NECs regarding their prognosis, they are now further classified according to TNM-stage systems that were recently proposed by the European Neuroendocrine Tumour Society (ENETS) and the AJCC/UICC. In the light of these criteria the pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed. 
Zeitschriftentitel:
Endocr Relat Cancer 
Jahr:
2011 
Band / Volume:
18 Suppl 1 
Seitenangaben Beitrag:
S1-S16 
Sprache:
eng 
Print-ISSN:
1351-0088 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie