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Dokumenttyp:
journal article 
Autor(en):
Eser, S; Messer, M; Eser, P; von Werder, A; Seidler, B; Bajbouj, M; Vogelmann, R; Meining, A; von Burstin, J; Algül, H; Pagel, P; Schnieke, AE; Esposito, I; Schmid, RM; Schneider, G; Saur, D 
Titel:
In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor patient outcome often resulting from late diagnosis in advanced stages. To date methods to diagnose early-stage PDAC are limited and in vivo detection of pancreatic intraepithelial neoplasia (PanIN), a preinvasive precursor of PDAC, is impossible. Using a cathepsin-activatable near-infrared probe in combination with flexible confocal fluorescence lasermicroscopy (CFL) in a genetically defined mouse model of PDAC we were able to...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2011 
Band / Volume:
108 
Heft / Issue:
24 
Seitenangaben Beitrag:
9945-50 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie