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Document type:
journal article 
Author(s):
Ott, K; Rachakonda, PS; Panzram, B; Keller, G; Lordick, F; Becker, K; Langer, R; Buechler, M; Hemminki, K; Kumar, R 
Title:
DNA Repair Gene and MTHFR Gene Polymorphisms as Prognostic Markers in Locally Advanced Adenocarcinoma of the Esophagus or Stomach Treated with Cisplatin and 5-Fluorouracil-Based Neoadjuvant Chemotherapy. 
Abstract:
DNA repair plays an important role in chemoresistance to platinum-based therapy, and therefore polymorphisms in the genes may modulate therapeutic response. We assessed 12 polymorphisms in 7 DNA repair genes and 2 polymorphisms in the MTHFR gene for association with disease response and prognosis.A total of 258 patients included in the study had adenocarcinoma of the esophagus (n = 114) or gastric cancer (n = 144), at stage cT3/4 and cM0, and had been treated with platinum-based neoadjuvant poly...    »
 
Journal title abbreviation:
Ann Surg Oncol 
Year:
2011 
Journal volume:
18 
Journal issue:
Pages contribution:
2688-98 
Language:
eng 
Print-ISSN:
1068-9265 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie