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Dokumenttyp:
journal article 
Autor(en):
Depboylu, C; Schorlemmer, K; Klietz, M; Oertel, WH; Weihe, E; Höglinger, GU; Schäfer, MK 
Titel:
Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease. 
Abstract:
Here we analyzed C1q, the initial recognition subcomponent of classical complement activation cascade, in an experimental model of Parkinson disease (PD). Nigrostriatal dopaminergic pathway injury was induced by treatment of wildtype mice subchronically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Constitutive expression of C1q was restricted to microglia throughout the brain, and microglial C1q expression was early and transiently upregulated after MPTP in the substantia nigra (SN)...    »
 
Zeitschriftentitel:
J Neuroimmunol 
Jahr:
2011 
Band / Volume:
236 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
39-46 
Sprache:
eng 
Print-ISSN:
0165-5728 
TUM Einrichtung:
Neurologische Klinik und Poliklinik