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Dokumenttyp:
journal article 
Autor(en):
Berod, L; Heinemann, C; Heink, S; Escher, A; Stadelmann, C; Drube, S; Wetzker, R; Norgauer, J; Kamradt, T 
Titel:
PI3K? deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome. 
Abstract:
PI3Ks control signal transduction triggered by growth factors and G-protein-coupled receptors and regulate an array of biological processes, including cellular proliferation, differentiation, survival and migration. Herein, we investigated the role of PI3K? in the pathogenesis of EAE. We show that, in the absence of PI3K? expression, clinical signs of EAE were delayed and mitigated. PI3K?-deficient myelin oligodendrocyte glycoprotein (MOG)(35-55) -specific CD4(+) T cells appeared later in the se...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2011 
Band / Volume:
41 
Heft / Issue:
Seitenangaben Beitrag:
833-44 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Neurologische Klinik und Poliklinik