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Document type:
journal article 
Author(s):
Saft, C; Epplen, JT; Wieczorek, S; Landwehrmeyer, GB; Roos, RA; de Yebenes, JG; Dose, M; Tabrizi, SJ; Craufurd, D; REGISTRY Investigators of the European Huntington's Disease Network; Arning, L; Barth, K; Bascuñana Garde, M; Bos, R; Ecker, D; Handley, O; Heinonen, N; Held, C; Laurà, M; Martínez Descals, A; Mestre, T; Monza, D; Naji, J; Orth, M; Padieu, H; Pro Koivisto, S; Rialland, A; Sasinková, P; Trigo Cubillo, P; van Walsem, M; Witjes-Ané, MN; Zielonka, D; Bonelli, R; Herranhof, B; Hödl, A; K...    »
 
Title:
NMDA receptor gene variations as modifiers in Huntington disease: a replication study. 
Abstract:
Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the "REGISTRY" cohort from the European Huntington Disease Network (EHDN). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and AO in the ent...    »
 
Journal title abbreviation:
PLoS Curr 
Year:
2011 
Journal volume:
Pages contribution:
RRN1247 
Language:
eng 
TUM Institution:
Neurologische Klinik und Poliklinik