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Document type:
journal article 
Author(s):
Loschko, J; Heink, S; Hackl, D; Dudziak, D; Reindl, W; Korn, T; Krug, AB 
Title:
Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. 
Abstract:
Plasmacytoid dendritic cells (PDCs) have been shown to present Ags and to contribute to peripheral immune tolerance and to Ag-specific adaptive immunity. However, modulation of adaptive immune responses by selective Ag targeting to PDCs with the aim of preventing autoimmunity has not been investigated. In the current study, we demonstrate that in vivo Ag delivery to murine PDCs via the specifically expressed surface molecule sialic acid binding Ig-like lectin H (Siglec-H) inhibits Th cell and Ab...    »
 
Journal title abbreviation:
J Immunol 
Year:
2011 
Journal volume:
187 
Journal issue:
12 
Pages contribution:
6346-56 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
II. Medizinische Klinik und Poliklinik; Neurologische Klinik und Poliklinik