Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Sun, X; Fratz, S; Sharma, S; Hou, Y; Rafikov, R; Kumar, S; Rehmani, I; Tian, J; Smith, A; Schreiber, C; Reiser, J; Naumann, S; Haag, S; Hess, J; Catravas, JD; Patterson, C; Fineman, JR; Black, SM 
Titel:
C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow. 
Abstract:
We showed that nitric oxide (NO) signaling is decreased in the pulmonary vasculature before the development of endothelial dysfunction in a lamb model of congenital heart disease and increased pulmonary blood flow (Shunt). The elucidation of the molecular mechanism by which this occurs was the purpose of this study. Here, we demonstrate that concentrations of the endogenous NO synthase (NOS) inhibitor, asymmetric dimethylarginine (ADMA), are elevated, whereas the NOS cofactor tetrahydrobiopterin...    »
 
Zeitschriftentitel:
Am J Respir Cell Mol Biol 
Jahr:
2011 
Band / Volume:
45 
Heft / Issue:
Seitenangaben Beitrag:
163-71 
Sprache:
eng 
Print-ISSN:
1044-1549 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler; chirurgie