Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Lehmann-Horn, K; Schleich, E; Hertzenberg, D; Hapfelmeier, A; Kümpfel, T; von Bubnoff, N; Hohlfeld, R; Berthele, A; Hemmer, B; Weber, MS 
Titel:
Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders. 
Abstract:
Clinical trials evaluating anti-CD20-mediated B-cell depletion in multiple sclerosis (MS) and neuromyelitis optica (NMO) generated encouraging results. Our recent studies in the MS model experimental autoimmune encephalomyelitis (EAE) attributed clinical benefit to extinction of activated B-cells, but cautioned that depletion of naïve B-cells may be undesirable. We elucidated the regulatory role of un-activated B-cells in EAE and investigated whether anti-CD20 may collaterally diminish regulator...    »
 
Zeitschriftentitel:
J Neuroinflammation 
Jahr:
2011 
Band / Volume:
Seitenangaben Beitrag:
146 
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie; III. Medizinische Klinik und Poliklinik