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Dokumenttyp:
journal article 
Autor(en):
Elstner, M; Morris, CM; Heim, K; Bender, A; Mehta, D; Jaros, E; Klopstock, T; Meitinger, T; Turnbull, DM; Prokisch, H 
Titel:
Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death. 
Abstract:
Dopaminergic (DA) neuron degeneration is a feature of brain aging but is markedly increased in patients with Parkinson's disease (PD). Recent data indicate elevated metabolic stress as a possible explanation for DA neuron vulnerability. Using laser capture microdissection, we isolated DA neurons from the substantia nigra pars compacta of PD patients, age-matched and young controls to determine transcriptional changes by expression profiling and pathway analysis. We verified our findings by compa...    »
 
Zeitschriftentitel:
Acta Neuropathol (Berl) 
Jahr:
2011 
Band / Volume:
122 
Heft / Issue:
Seitenangaben Beitrag:
75-86 
Sprache:
eng 
Print-ISSN:
0001-6322 
TUM Einrichtung:
r Humangenetik