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Dokumenttyp:
journal article 
Autor(en):
Braren, I; Greunke, K; Pilette, C; Mempel, M; Grunwald, T; Bredehorst, R; Ring, J; Spillner, E; Ollert, M 
Titel:
Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains. 
Abstract:
Anti-IgE therapeutics represent an efficient approach in the management of IgE-mediated allergic asthma. However, monitoring the reduction of IgE levels into a therapeutically efficient range requires the determination of residual serum IgE. We established an analytical approach to distinguish free and anti-IgE complexed serum IgE based on soluble derivatives of the human high-affinity IgE receptor. Soluble receptor derivatives represent an ideal means to analyze receptor antagonism by any ligan...    »
 
Zeitschriftentitel:
Anal Biochem 
Jahr:
2011 
Band / Volume:
412 
Heft / Issue:
Seitenangaben Beitrag:
134-40 
Sprache:
eng 
Print-ISSN:
0003-2697 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung; r Dermatologie und Allergologie