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Document type:
journal article 
Author(s):
Mankan, AK; Canli, O; Schwitalla, S; Ziegler, P; Tschopp, J; Korn, T; Greten, FR 
Title:
TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. 
Abstract:
Loss of I?B kinase (IKK) ?-dependent NF-?B signaling in hematopoietic cells is associated with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes neutrophilia in Ikk?-deficient mice. TNF-?-dependent apoptosis of myeloid progenitor cells leads to the release of IL-1?, which promotes Th17 polarization of peripheral CD4(+) T cells. Although the elevation of IL-17 and the consecutive induction of granulocyte colony-stimulating factor compensate for the loss of myeloid...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2011 
Journal volume:
108 
Journal issue:
16 
Pages contribution:
6567-72 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Molekulare Immunologie ; Neurologische Klinik und Poliklinik