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Dokumenttyp:
journal article 
Autor(en):
Sato, S; Kopitz, C; Grismayer, B; Beaufort, N; Reuning, U; Schmitt, M; Luther, T; Kotzsch, M; Krüger, A; Magdolen, V 
Titel:
Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo. 
Abstract:
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice variants of this receptor have been reported. One of these, uPAR-del4/5, lacking exons 4 and 5, and thus encoding a uPAR form lacking domain DII, is specifically overexpressed in breast cancer and represents a statistically independent prognostic factor for distant metastasis-free survival in breast cancer patients. The aim of the present study was t...    »
 
Zeitschriftentitel:
Breast Cancer Res Treat 
Jahr:
2011 
Band / Volume:
127 
Heft / Issue:
Seitenangaben Beitrag:
649-57 
Sprache:
eng 
Print-ISSN:
0167-6806 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung; Frauenklinik und Poliklinik