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Document type:
journal article 
Author(s):
Leithner, C; Royl, G; Offenhauser, N; Füchtemeier, M; Kohl-Bareis, M; Villringer, A; Dirnagl, U; Lindauer, U 
Title:
Pharmacological uncoupling of activation induced increases in CBF and CMRO2. 
Abstract:
Neurovascular coupling provides the basis for many functional neuroimaging techniques. Nitric oxide (NO), adenosine, cyclooxygenase, CYP450 epoxygenase, and potassium are involved in dilating arterioles during neuronal activation. We combined inhibition of NO synthase, cyclooxygenase, adenosine receptors, CYP450 epoxygenase, and inward rectifier potassium (Kir) channels to test whether these pathways could explain the blood flow response to neuronal activation. Cerebral blood flow (CBF) and cere...    »
 
Journal title abbreviation:
J Cereb Blood Flow Metab 
Year:
2010 
Journal volume:
30 
Journal issue:
Pages contribution:
311-22 
Language:
eng 
Print-ISSN:
0271-678X 
TUM Institution:
Neurochirurgische Klinik und Poliklinik