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Dokumenttyp:
journal article 
Autor(en):
Matt, L; Michalakis, S; Hofmann, F; Hammelmann, V; Ludwig, A; Biel, M; Kleppisch, T 
Titel:
HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. 
Abstract:
Neuronal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to modulate spontaneous activity, resting membrane potential, input resistance, afterpotential, rebound activity, and dendritic integration. To evaluate the role of HCN2 for hippocampal synaptic plasticity, we recorded long-term potentiation (LTP) in the direct perforant path (PP) to CA1 pyramidal cells. LTP was enhanced in mice carrying a global deletion of the channel (HCN2(-/-)) but not in a pyramidal neuron...    »
 
Zeitschriftentitel:
Cell Mol Life Sci 
Jahr:
2011 
Band / Volume:
68 
Heft / Issue:
Seitenangaben Beitrag:
125-37 
Sprache:
eng 
Print-ISSN:
1420-682X 
TUM Einrichtung:
r Pharmakologie und Toxikologie