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Document type:
journal article 
Author(s):
Leiss, V; Friebe, A; Welling, A; Hofmann, F; Lukowski, R 
Title:
Cyclic GMP kinase I modulates glucagon release from pancreatic ?-cells. 
Abstract:
The physiologic significance of the nitric oxide (NO)/cGMP signaling pathway in islets is unclear. We hypothesized that cGMP-dependent protein kinase type I (cGKI) is directly involved in the secretion of islet hormones and glucose homeostasis.Gene-targeted mice that lack cGKI in islets (conventional cGKI mutants and cGKI? and I? rescue mice [?/?RM] that express cGKI only in smooth muscle) were studied in comparison to control (CTR) mice. cGKI expression was mapped in the endocrine pancreas by W...    »
 
Journal title abbreviation:
Diabetes 
Year:
2011 
Journal volume:
60 
Journal issue:
Pages contribution:
148-56 
Language:
eng 
Print-ISSN:
0012-1797 
TUM Institution:
Institut für Pharmakologie und Toxikologie