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Document type:
journal article 
Author(s):
Enes, J; Langwieser, N; Ruschel, J; Carballosa-Gonzalez, MM; Klug, A; Traut, MH; Ylera, B; Tahirovic, S; Hofmann, F; Stein, V; Moosmang, S; Hentall, ID; Bradke, F 
Title:
Electrical activity suppresses axon growth through Ca(v)1.2 channels in adult primary sensory neurons. 
Abstract:
Primary sensory neurons of the dorsal root ganglia (DRG) regenerate their spinal cord axon if the peripheral nerve axon has previously been cut. This conditioning lesion confers axon growth competence to the neurons. However, the signal that is sensed by the cell upon peripheral lesion to initiate the regenerative response remains elusive.We show here that loss of electrical activity following peripheral deafferentiation is an important signal to trigger axon regrowth. We first verified that fir...    »
 
Journal title abbreviation:
Curr Biol 
Year:
2010 
Journal volume:
20 
Journal issue:
13 
Pages contribution:
1154-64 
Language:
eng 
Print-ISSN:
0960-9822 
TUM Institution:
Institut für Pharmakologie und Toxikologie