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Document type:
journal article 
Author(s):
Ohler, A; Debela, M; Wagner, S; Magdolen, V; Becker-Pauly, C 
Title:
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation. 
Abstract:
The metalloproteases meprin alpha and beta are expressed in several tissues, leukocytes, and cancer cells. In skin, meprins are located in separate layers of human epidermis indicating distinct physiological functions, supported by effects on cultured keratinocytes. Meprin beta induces a dramatic change in cell morphology and a significant reduction in cell number, whereas in vitro evidence suggests a role for meprin alpha in basal keratinocyte proliferation. Meprins are secreted as zymogens tha...    »
 
Journal title abbreviation:
Biol Chem 
Year:
2010 
Journal volume:
391 
Journal issue:
Pages contribution:
455-60 
Language:
eng 
Print-ISSN:
1431-6730 
TUM Institution:
Frauenklinik und Poliklinik