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Dokumenttyp:
journal article 
Autor(en):
Beaufort, N; Plaza, K; Utzschneider, D; Schwarz, A; Burkhart, JM; Creutzburg, S; Debela, M; Schmitt, M; Ries, C; Magdolen, V 
Titel:
Interdependence of kallikrein-related peptidases in proteolytic networks. 
Abstract:
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short pro-peptide. We searched for interconnection of KLKs within extracellular proteolytic networks leading to activation of protease zymogens and found that (i) pro-KLK activation by other KLKs is scarce, with the exception of pro-KLK11, which is efficiently activated by KLK4...    »
 
Zeitschriftentitel:
Biol Chem 
Jahr:
2010 
Band / Volume:
391 
Heft / Issue:
Seitenangaben Beitrag:
581-7 
Sprache:
eng 
Print-ISSN:
1431-6730 
TUM Einrichtung:
Frauenklinik und Poliklinik