4G/5G polymorphism and haplotypes of SERPINE1 in atherosclerotic diseases of coronary arteries.

Koch, W; Schrempf, M; Erl, A; Mueller, JC; Hoppmann, P; Schömig, A; Kastrati, A

doi:10.1160/TH09-10-0702

journal article

Document type:: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Article
Author(s):: Koch, W; Schrempf, M; Erl, A; Mueller, JC; Hoppmann, P; Schömig, A; Kastrati, A
Title:: 4G/5G polymorphism and haplotypes of SERPINE1 in atherosclerotic diseases of coronary arteries.
Abstract:: We assessed the association between common variation at the SERPINE1 (PAI1) locus and myocardial infarction (MI). Haplotype-tagging polymorphisms, including the 4G/5G deletion/insertion polymorphism and seven single nucleotide polymorphisms, were analysed in a German sample containing 3,657 cases with MI and 1,211 controls. The association between the 4G/5G polymorphism and MI was examined in a meta-analysis of data extracted from 32 studies (13,267 cases/14,716 controls). In addition, the relation between the 4G/5G polymorphism and coronary diseases, comprising MI, coronary artery disease, coronary heart disease, or the acute coronary syndrome, was assessed in a combined analysis enclosing 43 studies (17,278 cases/18,039 controls). None of the tagging polymorphisms was associated with MI in the present sample (p 1.0%) 8-marker haplotypes was related to the risk of MI. In a meta-analysis specifically addressing the association with MI, no elevated risk was found in the carriers of the 4G allele (OR 1.07, 95% CI 0.99-1.16; p = 0.11). A more general combined analysis of coronary diseases showed a marginally increased risk in 4G allele carriers (OR 1.08, 95% CI 1.00-1.16; p = 0.044). In essence, tagging polymorphisms, including the 4G/5G polymorphism, and common haplotypes of the SERPINE1 gene region were not associated with MI in a German sample, and no compelling evidence was obtained for a relationship of the 4G/5G polymorphism to MI and coronary atherosclerosis in a meta-analysis.
Journal title abbreviation:: Thromb Haemost
Year:: 2010
Journal volume:: 103
Journal issue:: 6
Pages contribution:: 1170-80
Language:: eng
Fulltext / DOI:: doi:10.1160/TH09-10-0702
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/20352162
Print-ISSN:: 0340-6245
TUM Institution:: I. Medizinische Klinik und Poliklinik (Kardiologie)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2010