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Dokumenttyp:
journal article 
Autor(en):
Hafner-Bratkovic, I; Bester, R; Pristovsek, P; Gaedtke, L; Veranic, P; Gaspersic, J; Mancek-Keber, M; Avbelj, M; Polymenidou, M; Julius, C; Aguzzi, A; Vorberg, I; Jerala, R 
Titel:
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. 
Abstract:
Prion diseases are fatal transmissible neurodegenerative diseases affecting many mammalian species. The normal prion protein (PrP) converts into a pathological aggregated form, PrP(Sc), which is enriched in the ?-sheet structure. Although the high resolution structure of the normal PrP was determined, the structure of the converted form of PrP remains inaccessible to high resolution techniques. To map the PrP conversion process we introduced disulfide bridges into different positions within the...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2011 
Band / Volume:
286 
Heft / Issue:
14 
Seitenangaben Beitrag:
12149-56 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Virologie