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Document type:
journal article 
Author(s):
Karpuj, MV; Gelibter-Niv, S; Tiran, A; Rambold, A; Tatzelt, J; Nunziante, M; Schatzl, HM 
Title:
Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides. 
Abstract:
We demonstrate that the levels of native as well as transfected prion protein (PrP) are lowered in various cell lines exposed to phosphorothioate oligodeoxynucleotides (PS-DNA) and can be rapidly reverted to their normal amounts by removal of PS-DNA. This transient modulation was independent of the glycosylation state of PrP, and in addition, all three PrP glycoforms were susceptible to PS-DNA treatment. Deletion of the N-terminal domain (amino acids 23-99), but not of the other domains of PrP,...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2011 
Journal volume:
286 
Journal issue:
Pages contribution:
6911-7 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Virologie