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Dokumenttyp:
journal article 
Autor(en):
Bailly-Maitre, B; Belgardt, BF; Jordan, SD; Coornaert, B; von Freyend, MJ; Kleinridders, A; Mauer, J; Cuddy, M; Kress, CL; Willmes, D; Essig, M; Hampel, B; Protzer, U; Reed, JC; Brüning, JC 
Titel:
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. 
Abstract:
The unfolded protein response (UPR) or endoplasmic reticulum (ER) stress response is a physiological process enabling cells to cope with altered protein synthesis demands. However, under conditions of obesity, prolonged activation of the UPR has been shown to have deteriorating effects on different metabolic pathways. Here we identify Bax inhibitor-1 (BI-1), an evolutionary conserved ER-membrane protein, as a novel modulator of the obesity-associated alteration of the UPR. BI-1 partially inhibit...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2010 
Band / Volume:
285 
Heft / Issue:
Seitenangaben Beitrag:
6198-207 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Virologie