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Dokumenttyp:
journal article 
Autor(en):
John, H; Eyer, F; Zilker, T; Thiermann, H 
Titel:
High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma. 
Abstract:
S-hyoscyamine (S-hyo) is a toxic tropane alkaloid from plants of the solanacea family, which is extracted for pharmaceutical purposes thereby undergoing racemization (atropine). Merely the S-hyo enantiomer acts as an antagonist of muscarinic receptors (MR). Nevertheless, racemic atropine is clinically administered in e.g. ophthalmology and for symptomatic therapy of acute poisoning with organophosphorus compounds (OPCs, e.g. pesticides, nerve agents). However, very limited data are available of...    »
 
Zeitschriftentitel:
Anal Chim Acta 
Jahr:
2010 
Band / Volume:
680 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
32-40 
Sprache:
eng 
Print-ISSN:
0003-2670 
TUM Einrichtung:
Toxikologische Abteilung