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Document type:
journal article 
Author(s):
Vaupel, P 
Title:
Metabolic microenvironment of tumor cells: a key factor in malignant progression. 
Abstract:
The hostile metabolic microenvironment of solid tumors, which is quite heterogeneous both spatially and temporally («4-D-heterogeneity »), can trigger malignant progression. Above all, acute and fluctuating hypoxia elicits multiple cellular response pathways that alter gene expression and phenotype (at moderate hypoxia with oxygen concentrations below 1%). Upon severe hypoxia (oxygen concentrations below 0.1%), genomic instability can lead to cell variants with adaptations favorable to survival....    »
 
Journal title abbreviation:
Exp Oncol 
Year:
2010 
Journal volume:
32 
Journal issue:
Pages contribution:
125-7 
Language:
eng 
Print-ISSN:
1812-9269 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie