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- Dokumenttyp:
- Journal Article
- Autor(en):
- Hannemann, A; Meisinger, C; Bidlingmaier, M; Döring, A; Thorand, B; Heier, M; Belcredi, P; Ladwig, KH; Wallaschofski, H; Friedrich, N; Schipf, S; Lüdemann, J; Rettig, R; Peters, J; Völzke, H; Seissler, J; Beuschlein, F; Nauck, M; Reincke, M
- Titel:
- Association of plasma aldosterone with the metabolic syndrome in two German populations.
- Abstract:
- Objective The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. Methods We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference >=94 cm (men (m)) and >>=80 cm (women (w)); high-density lipoprotein (HDL) cholesterol <1.0 mmol/l (m) and <1.3 mmol/l (w); blood pressure >=130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) >=8 mmol/l, fasting glucose (KORA F4) >=5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) >>=2.3 mmol/l, fasting triglycerides (KORA F4) >=1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study- and sex-specific PAC quintiles versus all lower quintiles. Results MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Conclusions Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.
- Zeitschriftentitel:
- Eur J Endocrinol
- Jahr:
- 2011
- Band / Volume:
- 164
- Heft / Issue:
- 5
- Seitenangaben Beitrag:
- 751-8
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1530/EJE-10-1074
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/21357289
- Print-ISSN:
- 0804-4643
- TUM Einrichtung:
- Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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