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Dokumenttyp:
journal article 
Autor(en):
Hannemann, A; Meisinger, C; Bidlingmaier, M; Döring, A; Thorand, B; Heier, M; Belcredi, P; Ladwig, KH; Wallaschofski, H; Friedrich, N; Schipf, S; Lüdemann, J; Rettig, R; Peters, J; Volzke, H; Seissler, J; Beuschlein, F; Nauck, M; Reincke, M 
Titel:
Association of plasma aldosterone with the metabolic syndrome in two German populations. 
Abstract:
Objective The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. Methods We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference>=94 cm (men (m)) and>>=80 cm (women (w)); high-density lipoprotein (HDL) cholesterol<1.0 mmol/l (m) and<1.3 mmol/l (w); blood pressure>=130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1)>=8 mmol/l, fasting glucose (KORA F4)>=5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1)>>=2.3 mmol/l, fasting triglycerides (KORA F4)>=1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study- and sex-specific PAC quintiles versus all lower quintiles. Results MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Conclusions Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders. 
Zeitschriftentitel:
Eur J Endocrinol 
Jahr:
2011 
Band / Volume:
164 
Heft / Issue:
Seitenangaben Beitrag:
751-8 
Sprache:
eng 
Print-ISSN:
0804-4643 
TUM Einrichtung:
r Psychosomatische Medizin und Psychotherapie