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Dokumenttyp:
journal article 
Autor(en):
Albrecht, I; Niesner, U; Janke, M; Menning, A; Loddenkemper, C; Kühl, AA; Lepenies, I; Lexberg, MH; Westendorf, K; Hradilkova, K; Grün, J; Hamann, A; Epstein, JA; Chang, HD; Tokoyoda, K; Radbruch, A 
Titel:
Persistence of effector memory Th1 cells is regulated by Hopx. 
Abstract:
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and are believed to play a pivotal role in driving chronic inflammation. Here, we identify homeobox only protein (Hopx) as a critical and selective regulator of the survival of Th1 effector/memory cells, both in vitro and in vivo. Expression of Hopx is induced by T-bet and increases upon repeated antigenic restimulation of Th1 cells. Accordingly, the expression of Hopx is low in peripheral, naïve Th cells, but hi...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2010 
Band / Volume:
40 
Heft / Issue:
11 
Seitenangaben Beitrag:
2993-3006 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie