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Dokumenttyp:
journal article 
Autor(en):
Molatore, S; Liyanarachchi, S; Irmler, M; Perren, A; Mannelli, M; Ercolino, T; Beuschlein, F; Jarzab, B; Wloch, J; Ziaja, J; Zoubaa, S; Neff, F; Beckers, J; Höfler, H; Atkinson, MJ; Pellegata, NS 
Titel:
Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. 
Abstract:
Pheochromocytomas are rare neoplasias of neural crest origin arising from chromaffin cells of the adrenal medulla and sympathetic ganglia (extra-adrenal pheochromocytoma). Pheochromocytoma that develop in rats homozygous for a loss-of-function mutation in p27Kip1 (MENX syndrome) show a clear progression from hyperplasia to tumor, offering the possibility to gain insight into tumor pathobiology. We compared the gene-expression signatures of both adrenomedullary hyperplasia and pheochromocytoma wi...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2010 
Band / Volume:
107 
Heft / Issue:
43 
Seitenangaben Beitrag:
18493-8 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie