Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schmidt, N; Gonzalez, E; Visekruna, A; Kühl, AA; Loddenkemper, C; Mollenkopf, H; Kaufmann, SH; Steinhoff, U; Joeris, T 
Titel:
Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis. 
Abstract:
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD), comprising Crohn s disease and ulcerative colitis, is characterised by chronic relapsing inflammation of the gut. Increased proteasome activity, associated with the expression of immunoproteasomes, was found to enhance proinflammatory signalling and thus promotes inflammation in patients with IBD. The aim of this study was to explore whether modulation of the proteasomal activity is a suitable therapeutic approach to limit inflammation in co...    »
 
Zeitschriftentitel:
Gut 
Jahr:
2010 
Band / Volume:
59 
Heft / Issue:
Seitenangaben Beitrag:
896-906 
Sprache:
eng 
Print-ISSN:
0017-5749 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie