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Dokumenttyp:
journal article 
Autor(en):
Rivino, L; Gruarin, P; Häringer, B; Steinfelder, S; Lozza, L; Steckel, B; Weick, A; Sugliano, E; Jarrossay, D; Kühl, AA; Loddenkemper, C; Abrignani, S; Sallusto, F; Lanzavecchia, A; Geginat, J 
Titel:
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function. 
Abstract:
Interleukin (IL)-10 produced by regulatory T cell subsets is important for the prevention of autoimmunity and immunopathology, but little is known about the phenotype and function of IL-10-producing memory T cells. Human CD4(+)CCR6(+) memory T cells contained comparable numbers of IL-17- and IL-10-producing cells, and CCR6 was induced under both Th17-promoting conditions and upon tolerogenic T cell priming with transforming growth factor (TGF)-beta. In normal human spleens, the majority of CCR6(...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2010 
Band / Volume:
207 
Heft / Issue:
Seitenangaben Beitrag:
565-77 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie