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Dokumenttyp:
journal article 
Autor(en):
Reimann, M; Lee, S; Loddenkemper, C; Dörr, JR; Tabor, V; Aichele, P; Stein, H; Dörken, B; Jenuwein, T; Schmitt, CA 
Titel:
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. 
Abstract:
Activated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked DNA damage response (DDR). In contrast, Myc activation-although producing a DDR as well-is known to primarily elicit an apoptotic countermeasure. Using the Emu-myc transgenic mouse lymphoma model, we show here in vivo that apoptotic lymphoma cells activate macrophages to secrete transforming growth factor beta (TGF-beta) as a critical non-ce...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2010 
Band / Volume:
17 
Heft / Issue:
Seitenangaben Beitrag:
262-72 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie