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Document type:
journal article 
Author(s):
Kilian, EG; Sadoni, S; Vicol, C; Kelly, R; van Hulst, K; Schwaiger, M; Kupatt, C; Boekstegers, P; Pillai, R; Channon, K; Hetzer, R; Reichart, B 
Title:
Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -. 
Abstract:
Increasing numbers of patients with advanced coronary artery disease have limited options for percutaneous and/or surgical revascularization. A prospective, randomized, phase I clinical multicenter trial was performed to assess the feasibility and safety of delivering a pro-angiogenic transcription factor termed "hypoxia inducible factor-1alpha", delivered to ischemic cardiac muscle via a type 2 adenoviral (Ad2HIF) vector.The 13 patients were included under the following criteria: 1 hypoperfused...    »
 
Journal title abbreviation:
Circ J 
Year:
2010 
Journal volume:
74 
Journal issue:
Pages contribution:
916-24 
Language:
eng 
Print-ISSN:
1346-9843 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik