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Document type:
journal article 
Author(s):
Stroh, A; Tsai, HC; Ping Wang, L; Zhang, F; Kressel, J; Aravanis, A; Santhanam, N; Deisseroth, K; Konnerth, A; Schneider, MB 
Title:
Tracking stem cell differentiation in the setting of automated optogenetic stimulation. 
Abstract:
Membrane depolarization has been shown to play an important role in the neural differentiation of stem cells as well as in the survival and function of mature neurons. Here we introduce a microbial opsin into embryonic stem cells and develop optogenetic technology for stem cell engineering applications, with an automated system for noninvasive modulation of embryonic stem cell differentiation employing fast optogenetic control of ion flux. Mouse embryonic stem cells (ESCs) were stably transduced...    »
 
Journal title abbreviation:
Stem Cells 
Year:
2010 
Language:
eng 
Print-ISSN:
1066-5099 
TUM Institution:
Abteilung für Neuroradiologie ; Institut für Neurowissenschaften