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Dokumenttyp:
journal article 
Autor(en):
Boecker, H; Weindl, A; Brooks, DJ; Ceballos-Baumann, AO; Liedtke, C; Miederer, M; Sprenger, T; Wagner, KJ; Miederer, I 
Titel:
GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study. 
Abstract:
Essential tremor is the most common movement disorder, but the underlying pathophysiology is not well understood. A primary overactivity of cerebellothalamic output pathways is the most conspicuous finding, as indicated by animal and human studies. It has been argued that this overactivity may be due to impaired central inhibition, and converging evidence points toward a potential role of gamma-aminobutyric acid (GABA) dysfunction in tremor generation. METHODS: Using (11)C-flumazenil and PET, we...    »
 
Zeitschriftentitel:
J Nucl Med 
Jahr:
2010 
Band / Volume:
51 
Heft / Issue:
Seitenangaben Beitrag:
1030-5 
Sprache:
eng 
Print-ISSN:
0161-5505 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik; Neurologische Klinik und Poliklinik; sthesiologie