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Document type:
journal article 
Author(s):
Petermann, F; Rothhammer, V; Claussen, MC; Haas, JD; Blanco, LR; Heink, S; Prinz, I; Hemmer, B; Kuchroo, VK; Oukka, M; Korn, T 
Title:
?? T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. 
Abstract:
Mice that lack interleukin-23 (IL-23) are resistant to T cell-mediated autoimmunity. Although IL-23 is a maturation factor for T helper 17 (Th17) cells, a subset of ?? T cells expresses the IL-23 receptor (IL-23R) constitutively. Using IL-23R reporter mice, we showed that ?? T cells were the first cells to respond to IL-23 during experimental autoimmune encephalomyelitis (EAE). Although ?? T cells produced Th17 cell-associated cytokines in response to IL-23, their major function was to prevent t...    »
 
Journal title abbreviation:
Immunity 
Year:
2010 
Journal volume:
33 
Journal issue:
Pages contribution:
351-63 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Neurologische Klinik und Poliklinik