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Dokumenttyp:
journal article 
Autor(en):
Thiel, U; Pirson, S; Müller-Spahn, C; Conrad, H; Busch, DH; Bernhard, H; Burdach, S; Richter, GH 
Titel:
Specific recognition and inhibition of Ewing tumour growth by antigen-specific allo-restricted cytotoxic T cells. 
Abstract:
Background:The development of a successful immunotherapy is hampered by an ineffective T-cell repertoire against tumour antigens and the inability of the patient's immune system to overcome tolerance-inducing mechanisms. Here, we test the specific recognition and lytical potential of allo-restricted CD8(+) T cells against Ewing tumour (ET) associated antigens Enhancer of Zeste, Drosophila Homolog 2 (EZH2), and Chondromodulin-I (CHM1) identified through previous microarray analysis.Methods:Follow...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2011 
Band / Volume:
104 
Heft / Issue:
Seitenangaben Beitrag:
948-56 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Kinderklinik und Poliklinik; III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene