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Dokumenttyp:
journal article 
Autor(en):
Roider, E; Jellbauer, S; Köhn, B; Berchtold, C; Partilla, M; Busch, DH; Rüssmann, H; Panthel, K 
Titel:
Invasion and destruction of a murine fibrosarcoma by Salmonella-induced effector CD8 T cells as a therapeutic intervention against cancer. 
Abstract:
We have developed a new vaccination strategy by using the Salmonella type III secretion system (T3SS) to translocate heterologous antigens into the cytosol of host cells. This leads to an efficient antigen-specific CD8 T cell induction. Recently, we have demonstrated the use of Salmonella's T3SS for the immunoprophylaxis of a solid tumor. The murine fibrosarcoma WEHI 164 was transfected with the DNA sequence encoding the MHC class I-peptide p60(217-225) from Listeria monocytogenes. In the presen...    »
 
Zeitschriftentitel:
Cancer Immunol Immunother 
Jahr:
2011 
Band / Volume:
60 
Heft / Issue:
Seitenangaben Beitrag:
371-80 
Sprache:
eng 
Print-ISSN:
0340-7004 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene