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Dokumenttyp:
journal article 
Autor(en):
Peschel, G; Kernschmidt, L; Cirl, C; Wantia, N; Ertl, T; Dürr, S; Wagner, H; Miethke, T; Rodríguez, N 
Titel:
Chlamydophila pneumoniae downregulates MHC-class II expression by two cell type-specific mechanisms. 
Abstract:
Chlamydophila pneumoniae was shown to prevent IFN gamma-inducible upregulation of MHC-class II molecules by secreting chlamydial protease-like activity factor (CPAF) into the cytosol of those host cells which support the complete bacterial replication cycle. CPAF acts by degrading upstream stimulatory factor 1 (USF-1). However, in cells like bone marrow-derived macrophages (BMM), which restrict chlamydial replication, we show that CPAF expression is barely detectable and the expression of USF-1...    »
 
Zeitschriftentitel:
Mol Microbiol 
Jahr:
2010 
Band / Volume:
76 
Heft / Issue:
Seitenangaben Beitrag:
648-61 
Sprache:
eng 
Print-ISSN:
0950-382X 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene