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Document type:
journal article 
Author(s):
Laika, B; Leucht, S; Heres, S; Schneider, H; Steimer, W 
Title:
Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome. 
Abstract:
Psychiatric pharmacotherapy with olanzapine is commonplace. We investigated the influence of CYP1A2*1F (-163A, rs762551) and serotonergic polymorphisms on olanzapine serum concentrations and clinical outcome in a naturalistic clinical setting. Included were 124 Caucasian psychiatric inpatients treated with olanzapine for at least 4 weeks with steady-state serum concentrations available for 73 patients. The CYP1A2*1F polymorphism was reported to affect the inducibility of CYP1A2. In our study pop...    »
 
Journal title abbreviation:
Pharmacogenomics J 
Year:
2010 
Journal volume:
10 
Journal issue:
Pages contribution:
20-9 
Language:
eng 
Print-ISSN:
1470-269X 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie ; Klinik und Poliklinik für Dermatologie und Allergologie