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Dokumenttyp:
journal article 
Autor(en):
Traenka, C; Remke, M; Korshunov, A; Bender, S; Hielscher, T; Northcott, PA; Witt, H; Ryzhova, M; Felsberg, J; Benner, A; Riester, S; Scheurlen, W; Grunewald, TG; von Deimling, A; Kulozik, AE; Reifenberger, G; Taylor, MD; Lichter, P; Butt, E; Pfister, SM 
Titel:
Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma. 
Abstract:
Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk medulloblastoma. Through mRNA expression profiling, we identified LIM and SH3 protein 1 (LASP1) as one of the most upregulated genes on chromosome 17q in tumors with 17q gain. In a...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2010 
Band / Volume:
70 
Heft / Issue:
20 
Seitenangaben Beitrag:
8003-14 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
Kinderklinik und Poliklinik