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Dokumenttyp:
journal article 
Autor(en):
Buckley, SM; Ulloa-Montoya, F; Abts, D; Oostendorp, RA; Dzierzak, E; Ekker, SC; Verfaillie, CM 
Titel:
Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line. 
Abstract:
The microenvironment wherein hematopoietic stem cells (HSC) reside orchestrates HSC self-renewal vs. differentiation decisions. Stromal cells derived from ontogenically divergent hematopoietic microenvironments can support HSC in vitro and have been used to decipher factors that influence HSC fate decisions. Employing stromal cell lines derived from the aorta-gonad-mesonephros and embryonic liver, we aim to identify secreted factors that maintain/expand HSC in vitro.We cultured murine lineage an...    »
 
Zeitschriftentitel:
Exp Hematol 
Jahr:
2011 
Band / Volume:
39 
Heft / Issue:
Seitenangaben Beitrag:
114-123.e1-5 
Sprache:
eng 
Print-ISSN:
0301-472X 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik