Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Mócsai, A; Ruland, J; Tybulewicz, VL 
Titel:
The SYK tyrosine kinase: a crucial player in diverse biological functions. 
Abstract:
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophi...    »
 
Zeitschriftentitel:
Nat Rev Immunol 
Jahr:
2010 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
387-402 
Sprache:
eng 
Print-ISSN:
1474-1733 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik