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Dokumenttyp:
journal article 
Autor(en):
Old, JB; Kratzat, S; Hoellein, A; Graf, S; Nilsson, JA; Nilsson, L; Nakayama, KI; Peschel, C; Cleveland, JL; Keller, UB 
Titel:
Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. 
Abstract:
The universal cyclin-dependent kinase inhibitor p27(Kip1) functions as a tumor suppressor, and reduced levels of p27(Kip1) connote poor prognosis in several human malignancies. p27(Kip1) levels are predominately regulated by ubiquitin-mediated turnover of the protein, which is marked for destruction by the E3 ubiquitin ligase SCF(Skp2) complex following its phosphorylation by the cyclin E-cyclin-dependent kinase 2 complex. Binding of phospho-p27(Kip1) is directed by the Skp2 F-box protein, and t...    »
 
Zeitschriftentitel:
Mol Cancer Res 
Jahr:
2010 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
353-62 
Sprache:
eng 
Print-ISSN:
1541-7786 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik