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Dokumenttyp:
journal article 
Autor(en):
Berezowska, S; Diermeier-Daucher, S; Brockhoff, G; Busch, R; Duyster, J; Grosu, AL; Schlegel, J 
Titel:
Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells. 
Abstract:
Targeted molecular therapies against the epidermal growth factor receptor (EGFR) are novel, promising and potentially radiosensitising therapeutic approaches in the treatment of glioblastoma, a highly malignant and treatment-refractory brain tumour. Despite a solid rational basis, specific EGFR inhibition has rendered only disappointing clinical results to date. We therefore evaluated the efficacy of additional inhibition of human epidermal growth factor receptor 2 (HER2), the'non-autonomous amp...    »
 
Zeitschriftentitel:
Int J Mol Med 
Jahr:
2010 
Band / Volume:
26 
Heft / Issue:
Seitenangaben Beitrag:
713-21 
Sprache:
eng 
Print-ISSN:
1107-3756 
TUM Einrichtung:
r Medizinische Statistik und Epidemiologie; III. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie