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Dokumenttyp:
journal article 
Autor(en):
Bogner, C; Dechow, T; Ringshausen, I; Wagner, M; Oelsner, M; Lutzny, G; Licht, T; Peschel, C; Pastan, I; Kreitman, RJ; Decker, T 
Titel:
Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression. 
Abstract:
Mantle cell lymphoma (MCL) is an incurable mature B cell proliferation, combining the unfavourable clinical features of aggressive and indolent lymphomas. The blastic variant of MCL has an even worse prognosis and new treatment options are clearly needed. We analysed the effects of BL22, an immunotoxin composed of the Fv portion of an anti- CD22 antibody fused to a 38-kDa Pseudomonas exotoxin-A fragment on four MCL cell lines as well as on primary cells of four MCL patients. Apoptosis induction...    »
 
Zeitschriftentitel:
Br J Haematol 
Jahr:
2010 
Band / Volume:
148 
Heft / Issue:
Seitenangaben Beitrag:
99-109 
Sprache:
eng 
Print-ISSN:
0007-1048 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik