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Document type:
journal article 
Author(s):
Haas, SC; Huber, R; Gutsch, R; Kandemir, JD; Cappello, C; Krauter, J; Duyster, J; Ganser, A; Brand, K 
Title:
ITD- and FL-induced FLT3 signal transduction leads to increased C/EBPbeta-LIP expression and LIP/LAP ratio by different signalling modules. 
Abstract:
FLT3 receptor-associated signalling plays a role in proliferation and leukaemia. The transcription factor C/EBPbeta may be involved in malignancy with its alternative translation product C/EBPbeta-LIP. We investigated a potential connection between FLT3 signalling and the C/EBPbeta system in FLT3-internal tandem duplication (ITD)-positive leukaemia cells and FLT3-ITD- or FLT3-wild type (WT)-transfected 32D cells. In FLT3-ITD-positive cells or when ITD sequences were inserted into the FLT3-WT rec...    »
 
Journal title abbreviation:
Br J Haematol 
Year:
2010 
Journal volume:
148 
Journal issue:
Pages contribution:
777-90 
Language:
eng 
Print-ISSN:
0007-1048 
TUM Institution:
III. Medizinische Klinik und Poliklinik