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Document type:
journal article 
Author(s):
Tiroch, KA; Sibbing, D; Koch, W; Roosen-Runge, T; Mehilli, J; Schömig, A; Kastrati, A 
Title:
Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events. 
Abstract:
The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with an increase in cardiovascular events.We tested the association of the presence of the ABCB1 (C/T) T-allele, CYP2C19*2 (G/A) A-allele, or CYP2C19*17 (C/T) T-allele with the primary end point o...    »
 
Journal title abbreviation:
Am Heart J 
Year:
2010 
Journal volume:
160 
Journal issue:
Pages contribution:
506-12 
Language:
eng 
Print-ISSN:
0002-8703 
TUM Institution:
I. Medizinische Klinik und Poliklinik